Drug induced diseases slideshare

Druginduced diseases focus of pharmacy manual managed. His research has resulted in the publication of nearly 50 journal articles, 6 book chapters and 40 research abstracts in addition to his coeditorship of druginduced diseases. Druginduced diseases refer to those adverse effects of drugs that are serious enough for the patient to consult a doctor or get hospitalized. Druginduced acne accounts for approximately 1% of druginduced skin reactions.

Prevention, detection, and management, second edition will help pharmacists, physicians, nurses, and other health care professional on the front lines of patient care and pharmacotherapy to expect the unexpected and to be more knowledgeable about. She was not told that the drug was not approved by the fda for her condition. Prevention, detection, and management, second edition will help pharmacists, physicians, nurses, and other health care professional on the front lines of patient care and pharmacotherapy to expect the unexpected and to be more knowledgeable about the risk of drug induced diseases. Sometimes patients will need prescription strength medication. Saima rani pharmde 8th semester slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Tisdales research has been funded by the american heart association, numerous foundations, and the pharmaceutical industry. What is druginduced parkinsonism, know its characteristics. Drug induced kidney disease 1 drug induced kidney disease 2 introduction. Common side effects include excessive sweating, nausea, rhinitis, and diarrhea.

Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Druginduced kidney disease 1 druginduced kidney disease 2 introduction. Drug induced kidney disease dikd clinical pharmacy by. Prevention, detection, and management begin by defining druginduced disease did as, an unintended effect of a drug that may result in morbidity or mortality with symptoms sufficient to prompt a patient to seek medial attention andor require hospitalization. Druginduced diseases focus of pharmacy manual managed care. Since the first edition of this book was published in 2005, numerous drugs have been withdrawn from the market in the united states as a result of morbidity andor mortality associated with drug induced diseases. Drug induced diseases did also called as iatrogenic diseases, are well known but least studied entity. Druginduced lupus erythematosus is similar but not identical to systemic lupus erythematosus sle. Despite best efforts to assure that all drugs are safe and effective, millions of patients each year develop drug induced diseases.

Drug induced toxicity navaneeth a msc environmental technology cusat. Drug induced pulmonary disease is defined as any lung disease caused by a drug or medication. Classic predisposing risk factors to drug induced liver disease include age, race, and sex. There are an estimated 15,000 to 30,000 cases of drug induced lupus per year in the united states. Many types of lung injury can result from medicines. Druginduced disease definition of druginduced disease by.

Jul 23, 2019 the form of parkinsonism that develops after being treated with particular medications is known as drug induced parkinsonism. Drug induced pulmonary diseases linkedin slideshare. An experience of a tertiary care teaching hospital from india. Physicians prescribe drugs to prevent or treat disease. Identify an approach to incorporating did wi the differential. Additional factors of interest are the relationship between the dose of the drug and the extent of metabolism of an individual agent. Ppt drug induced liver injury powerpoint presentation. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The last thing one would expect is that the medication used to relieve. Druginduced pulmonary toxicity is a diagnosis of exclusion. Druginduced liver injury dili remains one of the most challenging disorders faced by gastroenterologists.

Drug induced dyskinesia is an involuntary movement disorder. This condition can be suspected if the patient has been exposed to a likely causative drug, develops new signs and symptoms, and has a remittence of these symptoms once the drug is withheld. A definitive guide to drug induced disease now in its third edition, this comprehensive guide provides a detailed overview of diseases that result from drug therapy, arming healthcare professionals with critical knowledge to protect the health and welfare of their patients. Druginduced hepatic injury is of major concern to clinicians, pharmaceutical manufacturers, and regulators. Drug induced pseudorenal failure bun due to protein catabolism steroids, tetracyclines scr due to competitive inhibition of creatinine secretion trimethoprim, cimetidine, triamterene with trimethoprim 1535% rise scr fully expressed after 3 days more sig in pts with preexisting renal dysfunction can occur with normal doses completely. Druginduced diseases did also called as iatrogenic diseases, are well known but least studied entity.

The kidney is particularly vulnerable to drugs and other agents that cause renal damage. Since the first edition of this book was published in 2005, numerous drugs have been withdrawn from the market in the united states as a result of morbidity andor mortality associated with druginduced diseases. Identify the components of the history required to rule inout a drug causation. Specific examples of patients with drug induced diseases. Pepper professor of public health and preventive medicine professor of biostatistics and epidemiology, medicine, and pharmacology vice dean for institutional affairs university of. Drug induced liver disease comes in many types, and has many potential causes.

Druginduced neurologic conditions may result from singleagent drug regimens, but they are more likely to occur when multiple agents that confer risk are administered concomitantly. Prevention, detection, and management is a well organised, easy to use reference source that fills a sizeable gap in the available literature. Iatrogenic disease is the result of diagnostic and. They proceed to explore these effects via the 12 major sections of the text.

Although vertigo and difficulty maintaining balance tend to be temporary, severe loss of vestibular sensitivity may persist, sometimes permanently. Despite its low incidence in the general population, gastroenterologists must always. Drug induce liver disease mita linkedin slideshare. The manifestations of druginduced pulmonary diseases span the entire spectrum of pathophysiologic conditions of the respiratory tract. In the united states, druginduced liver injury dili is the most common cause of acute liver failure. Know the characteristics, epidemiology, treatment, diagnosis of drug induced parkinsonism. The demographic characteristics of druginduced lupus largely depend upon the populations most likely to receive the relevant drugs.

Druginduced ototoxicity ear, nose, and throat disorders. Drug induced hepatic injury is of major concern to clinicians, pharmaceutical manufacturers, and regulators. Druginduced thrombocytopenia is the most common druginduced hematologic disorders, with some reports suggesting that as many as 5% of patients who receive heparin develop heparininduced thrombocytopenia. Considering the physiologic and metabolic capacity of the lung, it is surprising that druginduced pulmonary disease is not more common. As with most drug induced diseases, the pathological changes are nonspecific. Drug induced diseases adverse drug reactions on the gastrointestinal tract, with references included. We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. Drug induced skin disorders is defined as any skin disorders caused by a drug or. A druginduced disease is defined as the unintended effect of a drug that results in mortality or morbidity with symptoms sufficient to prompt a patient to seek. Taking certain drugs during pregnancy can cause birth defects. Patients with pure drug induced parkinsonism will have normalization of their radioactive dopa uptake in the basal ganglia after elimination of precipitating drugs. Drug induced chronic cutaneous le is the rarest of the three forms.

Despite best efforts to ensure the safety and effectiveness of all drugs, millions of patients each year develop druginduced diseases. Find out about druginduced liver disease treatment, signs, and symptoms like itching, easy bruising, and jaundice, and learn how certain drugs can cause liver disease. Find out about drug induced liver disease treatment, signs, and symptoms like itching, easy bruising, and jaundice, and learn how certain drugs can cause liver disease. The demographic characteristics of drug induced lupus largely depend upon the populations most likely to receive the relevant drugs. Back to druginduced diseases, 3rd edition protect your patients. Classic predisposing risk factors to druginduced liver disease include age, race, and sex. Lesions resembling discoid lupus erythematosus dle have been the most common presentation, but le tumidus has. Prevention, detection, and management begin by defining drug induced disease did as, an unintended effect of a drug that may result in morbidity or mortality with symptoms sufficient to prompt a patient to seek medial attention andor require hospitalization. The lack of clear data on the mortality and morbidity of druginduced diseases did and related costs is in itself a problem, says another coeditor, douglas miller, pharmd, professor in the department of pharmacy practice in the college of pharmacy and health science at wayne state university in detroit. Druginduced pulmonary disease is lung disease brought on by a bad reaction to a medicine. Treatment with antipsychotic drugs and levodopa commonly used to treat parkinson disease are well recognized causes of druginduced dyskinesia. Drug induced acne accounts for approximately 1% of drug induced skin reactions.

Types of lung problems or diseases that may be caused by medicines include. Summary of diagnosis drug induced liver disease is a relatively common, but often unrecognized, cause of liver injury drugs are great imitators, capable of producing nearly any clinical scenario and histopathologic lesion when dealing with a liver biopsy from a patient with an undiagnosed liver disease, the diagnosis of drug. Males and females have been equally affected, and the mean age of onset has been 59 years. Anticonvulsant drug induced liver injury virtually all of the major antiepileptic drugs can cause hepatotoxicity, although a fatal outcome is rare. These drugs cause an autoimmune response the body attacks its own cells producing symptoms similar to those of sle. Further complicating matters is the fact that it has an unpredictable and heterogeneous course, ranging from an asymptomatic rise in liver enzymes to. It gives american society of healthsystem pharmacists 7272 wisconsin avenue bethesda, md 20814 this vital subject the comprehensive coverage that it deserves. Ashp ebooks sign in with your ashp username and password to access purchased ebooks in my library. A definitive guide to druginduced disease now in its third edition, this comprehensive guide provides a detailed overview of diseases that result from drug therapy, arming healthcare professionals with critical knowledge to protect the health and welfare of their patients. The eruption occurs 1 to 3 weeks after the causative agent is initiated. Identify the laboratory tests required to rule inout as drug induced causation. Drug induced lupus erythematosus is an autoimmune disorder similar to systemic lupus erythematosus sle caused by chronic use of certain drugs.

The form of parkinsonism that develops after being treated with particular medications is known as druginduced parkinsonism. Despite best efforts to assure that all drugs are safe and effective, millions of patients each year develop druginduced diseases. Drug induced liver diseases are diseases of the liver that are caused by physicianprescribed medications, overthecounter medications, vitamins, hormones, herbs, illicit recreational drugs, and environmental toxins. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Back to drug induced diseases, 3rd edition protect your patients. In the united states, drug induced liver injury dili is the most common cause of acute liver failure. Streptomycin tends to cause more damage to the vestibular portion than to the auditory portion of the inner ear.

Around 1 in 10 birth defects are caused by using overthecounter otc or prescription drugs during pregnancy. Chair and professor, department of biostatistics and epidemiology director. The manifestations of drug induced pulmonary diseases span the entire spectrum of pathophysiologic conditions of the respiratory tract. As with most druginduced diseases, the pathological changes are nonspecific. Identify the laboratory tests required to rule inout as druginduced causation. Prevention, detection, and management begin by defining druginduced disease did as, an unintended effect of a drug that may result in morbidity or mortality with symptoms sufficient to prompt a patient to. It is usually impossible to predict who will develop lung disease from a medicine. Apr 01, 2010 the lack of clear data on the mortality and morbidity of druginduced diseases did and related costs is in itself a problem, says another coeditor, douglas miller, pharmd, professor in the department of pharmacy practice in the college of pharmacy and health science at wayne state university in detroit. Signs and symptoms include repetitive and irregular motions of the mouth, face, limbs andor trunk. Drug induced pulmonary disease is lung disease brought on by a bad reaction to a medicine. Chair and professor, department of biostatistics and epidemiology director, center for clinical epidemiology and biostatistics george s. It is generally equally common in males and females, and more common in older people and white populations. Cevimeline is an oral cholinergic agent approved for symptomatic treatment of dry mouth in patients with sjogrens syndrome. While patients with unmasking of an underlying parkinsonism will have persistent diminished uptake after elimination of the precipitating medication burn and brook, 1993.

Druginduced liver disease comes in many types, and has many potential causes. Druginduced liver diseases are diseases of the liver that are caused by physicianprescribed medications, overthecounter medications, vitamins, hormones, herbs, illicit recreational drugs, and environmental toxins. Druginduced liver injury is a cause of acute and chronic liver disease the liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Druginduced birth defects teratogenic drugs causes. Also know which drugs can cause parkinsonism and how to differentiate between drug induced parkinsonism and parkinsonism disease. Know the characteristics, epidemiology, treatment, diagnosis of druginduced parkinsonism. Since the publication of the first edition of this book in 2005, numerous drugs have been withdrawn from the market in the united states because of morbidity andor mortality associated with druginduced disease. Related conditions are druginduced cutaneous lupus and. Thank you for your interest in spreading the word about the bmj. The kidney maintains the vital functions of clearing excess body fluid and removing metabolic and exogenous toxins from the blood. A high index of suspicion is often necessary to expeditiously establish the diagnosis.

If you continue browsing the site, you agree to the use of cookies on this website. Definition of druginduced liver disease medicinenet. Druginduced chronic cutaneous le is the rarest of the three forms. From there, you can view and download your ashp ebooks to the reader of your choice. Liz, a 54year old woman, was prescribed the heart drug amiodarone cordarone to treat a common heart condition. Some of the risk factors of dids are multiple chronic diseases, multiple physicians, hospitalization, medical or surgical procedures, long duration of medicine use, advancing age, female sex and a particular class of drugs 6,7,8. Identify risk factors for high probability did causation. It appears on average, eight months after starting the trigger medication. Ppt druginduced kidney disease powerpoint presentation. The term druginduced diseases sounds like a paradox. Therefore, the diagnosis is often difficult and, in most cases, is based on exclusion of all other possible causes. Druginduced lupus erythematosus is an autoimmune disorder similar to systemic lupus erythematosus sle caused by chronic use of certain drugs. This means your body attacks healthy tissue by mistake.

Hepatotoxicity from hepatic toxicity implies chemicaldriven liver damage. Drug induced neurologic conditions may result from singleagent drug regimens, but they are more likely to occur when multiple agents that confer risk are administered concomitantly. Loss of vestibular sensitivity causes difficulty walking, especially in the dark, and. There are an estimated 15,000 to 30,000 cases of druginduced lupus per year in the united states. Every part of the eye and all ocular functions could be affected adversely. Pepper professor of public health and preventive medicine professor of biostatistics and epidemiology, medicine, and pharmacology vice dean for institutional affairs university of pennsylvania. While beneficial therapeutically, almost all medications have untoward effects on various body tissues and functions, including the eye in which organ toxic reactions are readily detectable. Druginduced liver injury dili can develop following the use of many prescription and overthecounter drugs through a variety of mechanisms.